Endocrine Abstracts

A 87 year old woman admitted with complaints of hoarseness and a palpable mass which she noticed 1 week ago. She had hypothyroidism for 25 years. On examination, there was a hard and fixed palpable 4x4 cm mass on the right side of the neck. In laboratory evaluation, thyroid function tests were normal, thyroid auto-antibodies were positive, calcitonin was normal, C-reactive protein was 224 mg/l and liver and kidney function tests were normal. Thyroid ultrasonography revealed a ...

Objective: Thyroid nodules are one of the most common thyroid diseases. Ultrasonography is an reliable and the most commonly used imaging method in the evaluation of thyroid nodules with a high sensitivity (Sn) and specificity (Sp). The prevelance of obesity, especially severe obesity, is increasing at an alarming rate in the worldwide. Although obesity and thyroid disorders are related to each other, the pathological relationship between those is not clear. Several studies ha...

Introduction: Metformin is widely used as the first-line therapy for patients with type 2 diabetes, and its most common adverse effects are gastrointestinal. Metformin-associated lactic acidosis (MALA) is a rare but serious adverse effect in patients with type 2 diabetes or patients who attempt suicide with metformin overdose. Here, we report the case of a 22-year-old woman who developed severe lactic acidosis after high-dose metformin was taken for a suicide attempt.<p cl...

However ACTH secreting adenomas are one of the most common functional pituitary tumors, subtypes such as Crooke cell corticotroph adenoma(CCCA) are relatively rare. We present here a patient with CCCA who had severe hypercortisolism mimicking ectopic ACTH syndrome. A 69 years old female patient admitted to emergency department after a fall. On cranial MRI,’a 3.5x2.5x3cm mass appearance with a sellar-suprasellar location, which is compressing the optic chiasm, expanding th...

Patient is a 43 years old female without any known additional disease. A pituitary mass was seen in the cranial MRI taken due to the complaint of forgetfulness. Pituitary MRI of the patient revealed a ’large intrasellar mass of 3.2x3x2.3 cm, which expanded the sella and pressed the optic chiasm’. The patient didn’t describe any symptoms other than forgetfulness. She didn’t have galactorrhea, cushingoid or acromegaloid appearance. Patients laboratuary evalua...

Aim: Cardiac rhythm abnormalities have been documented in acromegalic patients. Our aim is to evaluate atrial electromechanical delay (EMD) with tissue doppler imaging (TDI) in patients with acromegaly.Material and methods: Fourty patients with acromegaly (13 patients with remission disease and 27 patients with active disease; 22 women and 18 men; mean aged 46.1±10.3 years), and 37 age- and sex-matched healthy controls were enrolled in the study. At...

Introduction: Ectopic ACTH secretion by pheochromocytoma causing Cushing’s syndrome has been reported rarely. Here, we present a patient with ectopic ACTH-dependent Cushing’s syndrome, caused by a pheochromocytoma with normal fractionated 24 h urinary catecholamines and metanephrines.Case report: A 48-year old female patient admitted to our clinics with the complaints of severe hypertension despite receiving anti hypertensive therapy. Severe he...

Introduction: In pregnancy, the incidence of Primary Hyperparathyroidism is 1%; and there are 80% adenoma, 15% parathyroid hyperplasia, 3% multiple adenoma, and 1% parathyroid carcinoma in its etiology. In pregnancy, serum calcium (Ca) levels may not rise as much as expected. This is associated with hypoalbuminemia, GFR increase, placental Ca transfer, and inhibition of PTH–related bone resorption by estrogen. In pregnancy, hyperparathyroidism is asymptomatic at a rate o...

Objective: Percutaneous laser ablation (PLA) is a new procedure utilized to decrease nodule volume in symptomatic thyroid nodules, to provide euthyroidism in autonomous hyperfunctioning nodules, and to decrease compressive symptoms palliatively in malignant nodules. Standard treatment in autonomous thyroid nodules is radioiodine and surgery. In this report, we aimed to present this case to demonstrate changes in nodule histopathology, which was undergone thyroidectomy two year...

AimIt is known that serum thyroglobulin (TG) can increase after fine-needle biopsy of thyroid nodules. We aimed to determine whether TG is increased after ultrasonography guided fine needle capillary biopsy (FNC) of suspicious cervical LNs in thyroidectomized patients and investigate the possible association between change in TG and cytology results.Material and methodsData of 188 patients who underwent FNC o...